Human anti dsDNA IgG ELISA Kit

cat#3100-HS

INTENDED USE

The Human anti-dsDNA IgG ELISA Kit is a high sensitivity immunoassay suitable for quantifying or titering IgG antibody activity specific for dsDNA in serum or plasma.

Other biological fluids, including tissue culture medium, may be validated for use. 

GENERAL INFORMATION

Antibodies reactive with autologous nuclear components, such as DNA and histones, can represent an autoimmune basis for pathological conditions such as systemic lupus

erythematosis (SLE) in humans, and in mice homozygous for the lymphoproliferation spontaneous mutation (Faslpr), a systemic autoimmunity with massive lymphadenopathy

associated with proliferation of aberrant T cells, arthritis and immune complex glomerulonephritis; these conditions include elevated levels of anti-dsDNA and other anti-nuclear

antibodies (ANA) which often increase as the individual ages.Recent investigations have focused on the role of innate immune mechanisms, including Toll-like receptors (TLRs)

and TH2 immunity, responding to the damage-associated molecular patterns of dying cells, as underlying cause of the anti-dsDNA type autoimmunity. These may be induced by

the expanded use of biological modifiers in the drug industry, which may include immunotherapeutic antibodies, vaccines and adjuvants.